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Article

Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.

Molecular and cellular biology - 1 Jun 2001

Paciotti V, Clerici M, Scotti M, Lucchini G, Longhese M P

Abstract excerpt

DNA damage checkpoints lead to the inhibition of cell cycle progression following DNA damage. The Saccharomyces cerevisiae Mec1 checkpoint protein, a phosphatidylinositol kinase-related protein, is required for transient cell cycle arrest in response to DNA damage or DNA replication defects. We show that mec1 kinase-deficient (mec1kd) mutants are indistinguishable from mec1Delta cells, indicating that the Mec1...

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Identifiers

PMID: 11359899
DOI: 10.1128/MCB.21.12.3913-3925.2001
PMCID: PMC87054

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