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Article

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.

Molecular and cellular biology - 1 Dec 2004

Clerici Michela, Baldo Veronica, Mantiero Davide, Lottersberger Francisca, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

In Saccharomyces cerevisiae, Mec1/ATR plays a primary role in sensing and transducing checkpoint signals in response to different types of DNA lesions, while the role of the Tel1/ATM kinase in DNA damage checkpoints is not as well defined. We found that UV irradiation in G(1) in the absence of Mec1 activates a Tel1/MRX-dependent checkpoint, which specifically inhibits the metaphase-to-anaphase transition....

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Source

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Identifiers

PMID: 15542824
DOI: 10.1128/MCB.24.23.10126-10144.2004
PMCID: PMC529042

Genes

ATM
ATR
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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