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Article

Non-catalytic function for ATR in the checkpoint response.

Cell cycle (Georgetown, Tex.) - 15 Aug 2007

McSherry Troy D, Kitazono Ana A, Javaheri Ali, Kron Stephen J, Mueller Paul R

Abstract excerpt

The ATR family of checkpoint kinases is essential for an appropriate response to genomic insults in eukaryotes. Included in this family are Mei-41 in Drosophila, Mec1 inS. cerevisiae, Rad3 in S. pombe, and ATR in vertebrates. These large kinases phosphorylateand modify multiple cell cycle and checkpoint factors, leading to cell cycle arrest, DNA repair, and induction of apoptosis. The catalytic domain of all ATR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17721080
DOI: 10.4161/cc.6.16.4553

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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