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Article

A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

Giannattasio Michele, Sommariva Elena, Vercillo Raffaella, Lippi-Boncambi Filippo, Liberi Giordano, Foiani Marco, Plevani Paolo, Muzi-Falconi Marco

Abstract excerpt

The Rad17-Mec3-Ddc1 complex is essential for the cellular response to genotoxic agents and is thought to be important for sensing DNA lesions. Deletion of any of the RAD17, MEC3 or DDC1 genes abolishes the G(1) and G(2) and impairs the intra-S DNA-damage checkpoints. We characterize a dominant-negative mec3-dn mutation that has an unexpected phenotype. It inactivates the G(1) checkpoint while it leaves the G(2)...

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Identifiers

PMID: 12271137
DOI: 10.1073/pnas.202463999
PMCID: PMC130575

Genes

ATM
RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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