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Article

Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.

Molecular biology of the cell - 1 Oct 2001

Gasch A P, Huang M, Metzner S, Botstein D, Elledge S J, Brown P O

Abstract excerpt

Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the cellular response to DNA damage, we used DNA microarrays to observe genomic expression in Saccharomyces cerevisiae...

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Share to DNA Damage
Share to DNA, Fungal
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Methyl Methanesulfonate

Share to Protein Kinases

Share to Radiation, Ionizing

Share to Sequence Homology

Source

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Identifiers

PMID: 11598186
DOI: 10.1091/mbc.12.10.2987
PMCID: PMC60150

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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