Article
Biological properties of human c-Ha-ras1 genes mutated at codon 12.
Nature - 1 Jan 2000
Seeburg P H, Colby W W, Capon D J, Goeddel D V, Levinson A D
Abstract excerpt
Vertebrate genomes contain proto-oncogenes whose enhanced expression or alteration by mutation seems to be involved in the development of naturally occurring tumours. These activated genes, usually assayed by their ability to induce the malignant transformation of NIH 3T3 cells, are frequently re...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Transformation, Neoplastic
- Codon
- DNA Restriction Enzymes
- Humans
- Mutation
- Oncogenes
- RNA, Messenger
- Transfection