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Article

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.

Nature - 1 Jan 2000

Jähner D, Jaenisch R

Abstract excerpt

The pattern of DNA methylation changes during development of eukaryotes, and hypomethylation frequently correlates with gene expression (for reviews see refs 1-4). A causal relationship between hypermethylation and gene inactivity has been established for retroviral genomes which are methylated de novo when inserted into the germ line of mice (ref. 5; for review, see ref. 6). The mutual interaction of the...

Topics

Alleles
Animals
Base Sequence
Cell Transformation, Neoplastic
Collagen Type I, alpha 1 Chain
DNA
DNA Restriction Enzymes
Genes, Viral
Methylation
Mice
Mice, Inbred C57BL
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Moloney murine leukemia virus

Nucleic Acid Hybridization

Source

Identifiers

PMID: 2989695
DOI: 10.1038/315594a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2989695-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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