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Article

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.

Nature - 1 Jan 2000

Jähner D, Jaenisch R

Abstract excerpt

The pattern of DNA methylation changes during development of eukaryotes, and hypomethylation frequently correlates with gene expression (for reviews see refs 1-4). A causal relationship between hypermethylation and gene inactivity has been established for retroviral genomes which are methylated de novo when inserted into the germ line of mice (ref. 5; for review, see ref. 6). The mutual interaction of the...

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PMID: 2989695
DOI: 10.1038/315594a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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