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Article

A targeted kappa immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells.

Molecular immunology - 1 Jul 1998

Hale M A, Garrard W T

Abstract excerpt

Previous studies employing ectopic integration of reporter genes have shown that the nuclear matrix association region (MAR) adjacent to the intronic enhancer of the mouse kappa immunoglobulin (Ig) gene is required for high level transcription of rearranged genes, demethylation, reduction of position effects and maximal somatic hypermutation in B cells. To test for the function of this MAR in its natural...

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PMID: 9823759
DOI: 10.1016/s0161-5890(98)00060-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A targeted kappa immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells.PMID 9823759Read ↗

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Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

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Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.Semantic proximity Read ↗

Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line.Semantic proximity Read ↗

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment regionSemantic proximity Read ↗

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.Semantic proximity Read ↗

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Ig kappa transgenes containing distal regions of the contig.Semantic proximity Read ↗

Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.Semantic proximity Read ↗

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