Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factors affecting de novo methylation of foreign DNA in mouse embryonic stem cells.

The Journal of biological chemistry - 20 Aug 1999

Hertz J M, Schell G, Doerfler W

Abstract excerpt

Integration of foreign DNA into an established host genome can lead to changes in methylation in both the inserted DNA and in host sequences and potentially alters transgene and cellular transcription patterns. This work addresses the questions of what factors influence de novo methylation, and whether the integration site or inserted DNA can affect de novo methylation. Homologous recombination was used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Enhancer Elements, Genetic

Share to Luciferases

Share to Mitochondrial Proteins

Share to Neomycin

Share to Stem Cells

Source

Identifiers

PMID: 10446198
DOI: 10.1074/jbc.274.34.24232

Genes

BLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors affecting de novo methylation of foreign DNA in mouse embryonic stem cells.PMID 10446198Read ↗

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.Semantic proximity Read ↗

Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3bSemantic proximity Read ↗

De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.Semantic proximity Read ↗

Destabilization of the human epigenome: consequences of foreign DNA insertions.Semantic proximity Read ↗

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cellsSemantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.Semantic proximity Read ↗

Distal transgene insertion affects CpG island maintenance during differentiation.Semantic proximity Read ↗

CpG content affects gene silencing in mice: evidence from novel transgenes.Semantic proximity Read ↗

A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes.Semantic proximity Read ↗

Sequence features of retrotransposons allow for epigenetic variability.Semantic proximity Read ↗

Sequence features of retrotransposons allow for epigenetic variabilitySemantic proximity Read ↗

DNA hypomethylation leads to elevated mutation rates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.