Article
Allele-specific demethylation at an imprinted mammalian promoter.
Nucleic acids research - 1 Jan 2007
Wood Andrew J, Bourc'his Déborah, Bestor Timothy H, Oakey Rebecca J
Abstract excerpt
A screen for imprinted genes on mouse Chromosome 7 recently identified Inpp5f_v2, a paternally expressed retrogene lying within an intron of Inpp5f. Here, we identify a novel paternally expressed variant of the Inpp5f gene (Inpp5f_v3) that shows a number of unusual features. Inpp5f_v3 initiates from a CpG-rich repeat region adjoining two B1 elements, despite previous reports that SINEs are generally excluded from...
Topics
- Alleles
- Animals
- Female
- Genomic Imprinting
- Inositol Polyphosphate 5-Phosphatases
- Male
- Methylation
- Mice
- Phosphoric Monoester Hydrolases
- Pregnancy
- Promoter Regions, Genetic