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Article

Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.

Immunology and cell biology - 1 Feb 2001

Jolly C J, Neuberger M S

Abstract excerpt

Following antigen encounter, immunoglobulin genes are diversified by somatic hypermutation. The mechanism by which this mutational process preferentially targets immunoglobulin genes is not known, but is likely linked to transcription. However, transcription is not sufficient to ensure mutability. Here, by polymerase chain reaction amplification of bisulfite-modified DNA, the pattern of demethylation within the...

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Identifiers

PMID: 11168618
DOI: 10.1046/j.1440-1711.2001.00968.x

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