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Article

De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.

Gene - 1 May 2002

Dodge Jonathan E, Ramsahoye Bernard H, Wo Z Galen, Okano Masaki, Li En

Abstract excerpt

DNA methyltransferases, Dnmt3a and Dnmt3b, are required for de novo methylation in embryonic stem (ES) cells and postimplantation embryos. However, the mechanism of de novo methylation is largely unknown. In this study, we have analyzed the sequence specificity of Dnmt3a and Dnmt3b during de novo methylation of murine Moloney leukemia virus provirus DNA in virus-infected ES cells. Provirus DNA from infected...

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PMID: 12036582
DOI: 10.1016/s0378-1119(02)00469-9

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Source receipt: pubmed, retrieved 7 Sept 2026.

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