Article
Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.
Molecular and cellular biology - 1 Oct 1991
Barker D D, Wu H, Hartung S, Breindl M, Jaenisch R
Abstract excerpt
The Mov13 mouse strain carries a mutation in the alpha 1(I) procollagen gene which is due to the insertion of a Moloney murine leukemia provirus into the first intron. This insertion results in the de novo methylation of the provirus and flanking DNA, the alteration of chromatin structure, and the transcriptional inactivity of the collagen promoter. To address the mechanism of mutagenesis, we reintroduced a...
Topics
- Alleles
- Animals
- Cell Line
- Collagen
- Introns
- Mice
- Moloney murine leukemia virus
- Mutagenesis, Insertional
- Mutation
- Proviruses
- Regulatory Sequences, Nucleic Acid
- Repetitive Sequences, Nucleic Acid