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Article

Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Hatanaka Yuki, Inoue Kimiko, Oikawa Mami, Kamimura Satoshi, Ogonuki Narumi, Kodama Eiichi N, Ohkawa Yasuyuki, Tsukada Yu-ichi, Ogura Atsuo

Abstract excerpt

Substantial proportions of mammalian genomes comprise repetitive elements including endogenous retrotransposons. Although these play diverse roles during development, their appropriate silencing is critically important in maintaining genomic integrity in the host cells. The major mechanism for retrotransposon silencing is DNA methylation, but the wave of global DNA demethylation that occurs after fertilization...

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Identifiers

PMID: 26546670
DOI: 10.1073/pnas.1512775112
PMCID: PMC4664303

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Source receipt: pubmed, retrieved 7 Sept 2026.

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