Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse DNA methyltransferase (MTase) deletion mutants that retain the catalytic domain display neither de novo nor maintenance methylation activity in vivo.

Biological chemistry - 1 May 1997

Zimmermann C, Guhl E, Graessmann A

Abstract excerpt

The mammalian genome encodes a DNA cytosine-5-methyltransferase (MTase) of about 170 kDa that is apparently responsible for both de novo and maintenance methylation at CpG sites. Both methylation activities have to be regulated accurately to ensure correct developmental and cell type-specific gene activity. Distorted DNA methylation patterns have been associated with cell aging and diseases such as cancer and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Northern
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Western

Share to Molecular Sequence Data

Share to Molecular Weight

Share to Mutation

Source

Identifiers

PMID: 9191026
DOI: 10.1515/bchm.1997.378.5.393

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse DNA methyltransferase (MTase) deletion mutants that retain the catalytic domain display neither de novo nor maintenance methylation activity in vivo.PMID 9191026Read ↗

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.Semantic proximity Read ↗

Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Semantic proximity Read ↗

Dissection of structure and function of the N-terminal domain of mouse DNMT1 using regional frame-shift mutagenesis.Semantic proximity Read ↗

<i>rahu</i> is a mutant allele of <i>Dnmt3c</i> , encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germlineSemantic proximity Read ↗

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read ↗

Identification of genetic elements that autonomously determine DNA methylation states.Semantic proximity Read ↗

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline.Semantic proximity Read ↗

Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints.Semantic proximity Read ↗

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.Semantic proximity Read ↗

Using human disease mutations to understand de novo DNA methyltransferase function.Semantic proximity Read ↗

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cellsSemantic proximity Read ↗

Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.