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Article

Impact of POR and CYP3A5 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in the Early Post-operative Period Following Kidney Transplantation.

Therapeutic drug monitoring - 1 Oct 2018

Phupradit Annop, Vadcharavivad Somratai, Ingsathit Atiporn, Kantachuvesiri Surasak, Areepium Nutthada, Sra-Ium Supasil, Auamnoy Titinun, Sukasem Chonlaphat, Sumethkul Vasant, Kitiyakara Chagriya

Abstract excerpt

BACKGROUND: Tacrolimus, a critical dose drug, is widely used in transplantation. Knowing the contribution of genetic factors, which significantly influence tacrolimus variability, is beneficial in the personalization of its starting dose. The significant impact of CYP3A5*3 polymorphisms on tacrolimus exposure has been reported. Conflicting results of the additional influence of POR*28 polymorphisms on tacrolimus...

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Share to Cytochrome P-450 CYP3A
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Immunosuppressive Agents

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Source

Identifiers

PMID: 29878980
DOI: 10.1097/FTD.0000000000000542

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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