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Article

Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients.

Pharmacogenomics - 1 Jan 2015

Li Jia-li, Liu Shu, Fu Qian, Zhang Yu, Wang Xue-ding, Liu Xiao-man, Liu Long-shan, Wang Chang-xi, Huang Min

Abstract excerpt

AIMS: To evaluate the influences of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tacrolimus concentration in early postrenal transplant recipients. PATIENTS & METHODS: A total of 159 patients were included, dose-adjusted tacrolimus trough concentration on day 7 after transplantation (C0D7/D) was calculated and 10 SNPs in four genes were genotyped. RESULTS: CYP3A5*3 explained 32.8% of variability of tacrolimus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26228923
DOI: 10.2217/pgs.15.78

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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