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The combination of CYP3A422 and CYP3A53 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation.

Pharmacogenetics and genomics - 1 Sept 2017

Lloberas Nuria, Elens Laure, Llaudó Ines, Padullés Ariadna, van Gelder Teun, Hesselink Dennis A, Colom Helena, Andreu Franc, Torras Joan, Bestard Oriol, Cruzado Josep M, Gil-Vernet Salvador, van Schaik Ron, Grinyó Josep M

Abstract excerpt

INTRODUCTION: Tacrolimus (Tac) has a narrow therapeutic window and shows large between-patient pharmacokinetic variability. As a result, over-immunosuppression and under-immunosuppression are frequently encountered in daily clinical practice. Unraveling the impact of genetic polymorphisms on Tac pharmacokinetics may help to refine therapy. In this study, the associations of single-nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 28704257
DOI: 10.1097/FPC.0000000000000296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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