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Article

Effect of CYP3A422, CYP3A53 and POR*28 genetic polymorphisms on calcineurin inhibitors dose requirements in early phase renal transplant patients.

Pharmacogenetics and genomics - 1 Feb 2024

Ebid Abdel-Hameed Im, Ismail Dina A, Lotfy Neama M, Mahmoud Mohamed A, El-Sharkawy Magdy

Abstract excerpt

OBJECTIVE: This study aimed to investigate the combined effect of CYP3A5*3, CYP3A4*22, and POR*28 genetic polymorphisms on tacrolimus and cyclosporine dose requirements. METHODS: One hundred thirty renal transplant patients placed on either tacrolimus or cyclosporine were recruited, where the effect of CYP3A5*3, CYP3A4*22, and POR*28 genetic polymorphisms on their dose requirements were studied at days 14, 30,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38050720
DOI: 10.1097/FPC.0000000000000516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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