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Article

Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus.

Therapeutic drug monitoring - 1 Jun 2015

Bruckmueller Henrike, Werk Anneke Nina, Renders Lutz, Feldkamp Thorsten, Tepel Martin, Borst Christoffer, Caliebe Amke, Kunzendorf Ulrich, Cascorbi Ingolf

Abstract excerpt

BACKGROUND: Tacrolimus is established as immunosuppressant after kidney transplantation. Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to tacrolimus dose requirements. Recently, CYP3A4*22 was reported to additionally affect tacrolimus pharmacokinetics (PK). In addition, there are further polymorphic genes, possibly influencing CYP3A activity [pregnane x receptor NR1I2, P450...

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Identifiers

PMID: 25271728
DOI: 10.1097/FTD.0000000000000142

Genes

POR
PPARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus.PMID 25271728Read ↗

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