Article
Effects of CYP3A5, ABCB1 and POR*28 polymorphisms on pharmacokinetics of tacrolimus in the early period after renal transplantation.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Dec 2020
Ling Jing, Dong Lu-Lu, Yang Xu-Ping, Qian Qing, Jiang Yan, Zou Su-Lan, Hu Nan
Abstract excerpt
1. We aimed to establish a population pharmacokinetic (PK) model of tacrolimus and identify clinical covariates, especially the genetic polymorphisms of CYP3A5, ABCB1 and POR*28 that affected the PK to prevent fluctuation in the trough concentration of tacrolimus during the early period after renal transplantation. 2. Tacrolimus trough concentration, clinical data and CYP3A5/ABCB1/POR28 genotypes were...
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