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Article

CYP3A53 and POR28 genetic variants influence the required dose of tacrolimus in heart transplant recipients.

Therapeutic drug monitoring - 1 Dec 2014

Lesche Dorothea, Sigurdardottir Vilborg, Setoud Raschid, Oberhänsli Markus, Carrel Thierry, Fiedler Georg M, Largiadèr Carlo R, Mohacsi Paul, Sistonen Johanna

Abstract excerpt

BACKGROUND: After heart transplantation (HTx), the interindividual pharmacokinetic variability of immunosuppressive drugs represents a major therapeutic challenge due to the narrow therapeutic window between over-immunosuppression causing toxicity and under-immunosuppression leading to graft rejection. Although genetic polymorphisms have been shown to influence pharmacokinetics of immunosuppressants, data in the...

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Share to Cytochrome P-450 CYP3A
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Rejection

Share to Heart Transplantation

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Source

Identifiers

PMID: 24739669
DOI: 10.1097/FTD.0000000000000080

Genes

POR
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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