Article
Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients.
Pharmacogenetics and genomics - 1 Dec 2014
Kuypers Dirk R J, de Loor Henriette, Naesens Maarten, Coopmans Tamara, de Jonge Hylke
Abstract excerpt
AIM: In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading dose of 0.2 mg/kg, the combined effects of the CYP3A5*1, POR*28, and CYP3A4*22 genotypes on early tacrolimus exposure (C0), dose requirements, and achievement of the therapeutic target, C0, were examined....
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