Article
Influence of POR*28 Polymorphisms on CYP3A5*3-Associated Variations in Tacrolimus Blood Levels at an Early Stage after Liver Transplantation.
International journal of molecular sciences - 26 Mar 2020
Nakamura Takahiro, Fukuda Mio, Matsukane Ryosuke, Suetsugu Kimitaka, Harada Noboru, Yoshizumi Tomoharu, Egashira Nobuaki, Mori Masaki, Masuda Satohiro
Abstract excerpt
It is well known that the CYP3A5*3 polymorphism is an important marker that correlates with the tacrolimus dose requirement after organ transplantation. Recently, it has been revealed that the POR*28 polymorphism affects the pharmacokinetics of tacrolimus in renal transplant patients. In this study, we examined whether POR*28 as well as CYP3A5*3 polymorphism in Japanese recipients and donors would be another...
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