Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.

doi:10.1002/em.20678

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Article

Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.

Environmental and molecular mutagenesis - 1 Dec 2011

Shi Jing, Krsmanovic Ljubica, Bruce Shannon, Kelly Tawney, Paranjpe Madhav, Szabo Kathleen, Arevalo Mirna, Atta-Safoh Samual, Debelie Fekado, LaForce Michelle Klug, Sly Jamie, Springer Sandra

Abstract excerpt

As part of the Stage 3 of the Pig-a international trial, we evaluated 7,12-dimethylbenz(a)anthracene (DMBA) for induction of Pig-a gene mutation using a 28-day repeat dose study design in Sprague-Dawley rats. In the same study, chromosomal damage in peripheral blood and primary DNA damage in liver were also investigated by the micronucleus (MN) assay and the Comet assay, respectively. In agreement with previously...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Bone Marrow
CD59 Antigens
Calibration
Comet Assay
Data Interpretation, Statistical
Diethylnitrosamine
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endpoint Determination

Erythrocytes

Flow Cytometry

Laboratories

Liver

Male

Membrane Proteins

Micronucleus Tests

Mutagenicity Tests

Source

Open in PubMed

Identifiers

PMID: 21976072
DOI: 10.1002/em.20678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21976072-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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