Article
The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes.
Nature genetics - 1 Jul 2018
Jacobs Jelle, Atkins Mardelle, Davie Kristofer, Imrichova Hana, Romanelli Lucia, Christiaens Valerie, Hulselmans Gert, Potier Delphine, Wouters Jasper, Taskiran Ibrahim I, Paciello Giulia, González-Blas Carmen B, Koldere Duygu, Aibar Sara, Halder Georg, Aerts Stein
Abstract excerpt
Transcriptional enhancers function as docking platforms for combinations of transcription factors (TFs) to control gene expression. How enhancer sequences determine nucleosome occupancy, TF recruitment and transcriptional activation in vivo remains unclear. Using ATAC-seq across a panel of Drosophila inbred strains, we found that SNPs affecting binding sites of the TF Grainy head (Grh) causally determine the...
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