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Article

Hairy transcriptional repression targets and cofactor recruitment in Drosophila.

PLoS biology - 1 Jul 2004

Bianchi-Frias Daniella, Orian Amir, Delrow Jeffrey J, Vazquez Julio, Rosales-Nieves Alicia E, Parkhurst Susan M

Abstract excerpt

Members of the widely conserved Hairy/Enhancer of split family of basic Helix-Loop-Helix repressors are essential for proper Drosophila and vertebrate development and are misregulated in many cancers. While a major step forward in understanding the molecular mechanism(s) surrounding Hairy-mediated repression was made with the identification of Groucho, Drosophila C-terminal binding protein (dCtBP), and Drosophila...

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Identifiers

PMID: 15252443
DOI: 10.1371/journal.pbio.0020178
PMCID: PMC449821

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