Article

HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation

2019-12-11

Abstract excerpt

<h4>Summary</h4> Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains with highly similar sequence recognition properties, yet they impart the identity of different ani...

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Literature Corpus work: df8c1df5-239d-52b4-8d4c-fe7831f33b3d
DOI: 10.1101/871640

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