Article
RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.
Epigenetics & chromatin - 4 Jun 2018
Okazaki Kosuke, Kato Hiroaki, Iida Tetsushi, Shinmyozu Kaori, Nakayama Jun-Ichi, Murakami Yota, Urano Takeshi
Abstract excerpt
BACKGROUND: Heat-shock molecular chaperone proteins (Hsps) promote the loading of small interfering RNA (siRNA) onto RNA interference (RNAi) effector complexes. While the RNAi process is coupled with heterochromatin assembly in several model organisms, it remains unclear whether the Hsps contribute to epigenetic gene regulation. In this study, we used the fission yeast Schizosaccharomyces pombe as a model...
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