Article
Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery.
Science (New York, N.Y.) - 30 Jan 2004
Pal-Bhadra Manika, Leibovitch Boris A, Gandhi Sumit G, Chikka Madhusudana Rao, Rao Madhusudana, Bhadra Utpal, Birchler James A, Elgin Sarah C R
Abstract excerpt
Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila melanogaster by position effect variegation (PEV). Loss-of-function mutations resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase. Here, we demonstrate that this silencing is dependent...
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