Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitis.

doi:10.1099/vir.0.18974-0

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Article

Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitis.

The Journal of general virology - 1 May 2003

Buttinelli Gabriele, Donati Valentina, Fiore Stefano, Marturano Jill, Plebani Alessandro, Balestri Paolo, Soresina Anna Rosa, Vivarelli Rossella, Delpeyroux Francis, Martin Javier, Fiore Lucia

Abstract excerpt

The molecular and antigenic properties of a Sabin-like type 2 poliovirus, isolated from the stool samples of a 2-year-old agammaglobulinaemic child who developed paralysis 1 year after receiving the third dose of oral poliovirus vaccine, were analysed. The virus revealed 0.88 % genome variation in the VP1 region compared with the standard reference strain, compatible with replication of the virus in the intestine...

Topics

5' Untranslated Regions
Agammaglobulinemia
Amino Acid Substitution
Animals
Capsid Proteins
Child, Preschool
Feces
Genetic Variation
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Poliomyelitis

Poliovirus

Poliovirus Vaccine, Oral

Sequence Analysis, DNA

Vaccines, Attenuated

Virulence

Source

Open in PubMed

Identifiers

PMID: 12692287
DOI: 10.1099/vir.0.18974-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12692287-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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