Article
Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: relevance to poliomyelitis eradication.
Journal of virology - 1 Sept 2006
Macadam Andrew J, Ferguson Geraldine, Stone David M, Meredith Janet, Knowlson Sarah, Auda Ghazi, Almond Jeffrey W, Minor Philip D
Abstract excerpt
The global eradication of poliomyelitis caused by wild-type virus is likely to be completed within the next few years, despite immense logistic and political difficulties, and may ultimately be followed by the cessation of vaccination. However, the existing live-attenuated vaccines have the poten...
Topics
- 5' Untranslated Regions
- Animals
- Cell Line
- Chlorocebus aethiops
- Drug Design
- Drug Stability
- Genotype
- Humans
- L Cells
- Mice
- Mutation
- Phenotype
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccines