Article
Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine.
Developments in biological standardization - 1 Jan 1993
Mento S J, Weeks-Levy C, Tatem J M, Gorgacz E J, Waterfield W F
Abstract excerpt
Sequence analysis of poliovirus vaccine RNA has resulted in the identification of a new point mutation at position 2493 in Sabin 3. cDNA-derived Sabin 3 virus whose genome includes the new mutation has phenotypic properties expected for a vaccine strain. Virus engineered to contain a single base substitution at 2493 has lost the small plaque phenotype, and low neurovirulence characteristics normally associated...
Topics
- Animals
- Base Composition
- DNA
- Humans
- Macaca mulatta
- Mice
- Mice, Transgenic
- Mutation
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral
- RNA, Viral