Article
Accurate Assembly and Typing of HLA using a Graph-Guided Assembler Kourami.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Lee Heewook, Kingsford Carl
Abstract excerpt
Accurate typing of human leukocyte antigen (HLA) is essential for successful organ transplantation and HLA genes are heavily associated with various diseases. Widely used typing assays often involve a set of specially designed primers or probes requiring additional experiments. With the maturing of high-throughput sequencing (HTS) technologies, whole genome sequencing (WGS) as well as other HTS assays are...
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