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High-throughput multiplex HLA genotyping by next-generation sequencing using multi-locus individual tagging

6 Oct 2014

Abstract excerpt

BACKGROUND: Unambiguous human leukocyte antigen (HLA) typing is important in transplant matching and disease association studies. High-resolution HLA typing that is not restricted to the peptide-binding region can decrease HLA allele ambiguities. Cost and technology constraints have hampered high-throughput and efficient high resolution unambiguous HLA typing. We have developed a method for HLA genotyping that...

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PMID: 25283548
DOI: 10.1186/1471-2164-15-864

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