Article
HLA typing from RNA-seq data using hierarchical read weighting [corrected].
PloS one - 1 Jan 2013
Kim Hyunsung John, Pourmand Nader
Abstract excerpt
Correctly matching the HLA haplotypes of donor and recipient is essential to the success of allogenic hematopoietic stem cell transplantation. Current HLA typing methods rely on targeted testing of recognized antigens or sequences. Despite advances in Next Generation Sequencing, general high throughput transcriptome sequencing is currently underutilized for HLA haplotyping due to the central difficulty in...
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