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Article

HLA typing from RNA-seq data using hierarchical read weighting [corrected].

PloS one - 1 Jan 2013

Kim Hyunsung John, Pourmand Nader

Abstract excerpt

Correctly matching the HLA haplotypes of donor and recipient is essential to the success of allogenic hematopoietic stem cell transplantation. Current HLA typing methods rely on targeted testing of recognized antigens or sequences. Despite advances in Next Generation Sequencing, general high throughput transcriptome sequencing is currently underutilized for HLA haplotyping due to the central difficulty in...

Topics

Alleles
Base Sequence
Cell Line
Computer Simulation
Haplotypes
High-Throughput Nucleotide Sequencing
Histocompatibility Testing
Humans
RNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23840783
DOI: 10.1371/journal.pone.0067885
PMCID: PMC3696101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23840783-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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