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Article

Hla-mapper: An application to optimize the mapping of HLA sequences produced by massively parallel sequencing procedures.

Human immunology - 1 Sept 2018

Castelli Erick C, Paz Michelle A, Souza Andréia S, Ramalho Jaqueline, Mendes-Junior Celso Teixeira

Abstract excerpt

A challenging task when more than one HLA gene is evaluated together by second-generation sequencing is to achieve a reliable read mapping. The polymorphic and repetitive nature of HLA genes might bias the read mapping process, usually underestimating variability at very polymorphic segments, or overestimating variability at some segments. To overcome this issue we developed hla-mapper, which takes into account...

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PMID: 30122171
DOI: 10.1016/j.humimm.2018.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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