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Article

Full-resolution HLA and KIR gene annotations for human genome assemblies.

Genome research - 20 Nov 2024

Zhou Ying, Song Li, Li Heng

Abstract excerpt

The human leukocyte antigen (HLA) genes and the killer cell immunoglobulin-like receptor (KIR) genes are critical to immune responses and are associated with many immune-related diseases. Located in highly polymorphic regions, it is difficult to study them with traditional short-read alignment-based methods. Although modern long-read assemblers can often assemble these genes, using existing tools to annotate HLA...

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Identifiers

PMID: 38839374
DOI: 10.1101/gr.278985.124
PMCID: PMC11610593

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