Article
Heterozygous IDH1R132H/WT created by "single base editing" inhibits human astroglial cell growth by downregulating YAP.
Oncogene - 1 Sept 2018
Wei Shuang, Wang Jie, Oyinlade Olutobi, Ma Ding, Wang Shuyan, Kratz Lisa, Lal Bachchu, Xu Qingfu, Liu Senquan, Shah Sagar R, Zhang Hao, Li Yunqing, Quiñones-Hinojosa Alfredo, Zhu Heng, Huang Zhi-Yong, Cheng Linzhao, Qian Jiang, Xia Shuli
Abstract excerpt
Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number of cancer types, including brain cancer. The Cancer Genome Atlas project has revealed that IDH1 mutations occur in 70-80% of grade II and grade III gliomas. Until recently, most of the functional studies of IDH1 mutations in cellular models have been conducted in overexpression systems with the IDH1 wild type background. In...
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