Back to search

Article

Orthogonal targeting of KDM6A/B and HDACs mediates potent therapeutic effects in <i>IDH1</i> -mutant glioma

2020-11-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> IDH1/2 -mutant gliomas are primary brain tumors for which curative treatments are lacking. Mutant IDH-dependent 2-hydroxyglutarate (2-HG) accumulation leads to DNA and histone hypermethylation. Based on this distinct phenotype, we interrogated epigenetic dependencies of IDH -mutant glioma that can be targeted therapeutically. <h4>Methods</h4> We conducted a chemical scree...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3000fa85-bc0c-55f5-8713-d6ad1e6bf9d3
DOI
10.1101/2020.11.26.400234
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Orthogonal targeting of KDM6A/B and HDACs mediates potent therapeutic effects in <i>IDH1</i> -mutant gliomaDOI 10.1101/2020.11.26.400234
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant gliomaSemantic proximity
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma.Semantic proximity
Long-term administration of the mutant IDH inhibitor DS-1001b suppresses the growth of IDH1-mutant glioma in vitro and in mouse xenograft models and alters epigenetic profiles.Semantic proximity
EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitorSemantic proximity
Therapies for IDH-Mutant Gliomas.Semantic proximity
KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis.Semantic proximity
IDH Inhibitors and Beyond: The Cornerstone of Targeted Glioma Treatment.Semantic proximity
Targeting IDH-Mutant Glioma.Semantic proximity
Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma.Semantic proximity
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors.Semantic proximity
Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell culturesSemantic proximity
The Role of Mutant IDH Inhibitors in the Treatment of Glioma.Semantic proximity
Select a neighboring publication to make it the new centre.