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Article

Mutant IDH1 Promotes Glioma Formation In Vivo

1 May 2018

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). A causal role for IDH1 R132H in gliomagenesis has been proposed, but functional validation in vivo has not been demonstrated. In this study, we assessed the role of IDH1 R132H in glioma development in the context of clinically relevant cooperating genetic alterations in vitro and in vivo ....

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 29719265
DOI: 10.1016/j.celrep.2018.03.133

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