Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDH1 mutation diminishes aggressive phenotype in glioma stem cells.

International journal of oncology - 1 Jan 2018

Yao Qi, Cai Gang, Yu Qi, Shen Jianhong, Gu Zhikai, Chen Jian, Shi Wei, Shi Jinlong

Abstract excerpt

The R132H mutation in isocitrate dehydrogenase 1 (IDH1-R132H) is associated with better prognosis in glioma patients. Glioma stem cells (GSCs) in glioma are believed to be responsible for glioma growth and maintenance. However, the relation between the R132H mutation and GSCs is not fully understood. In the present study, GSC markers were detected in patients with IDH1-R132H or wild-type IDH1 (IDH1-wt) by tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Glioma
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isocitrate Dehydrogenase

Share to Neoplastic Stem Cells

Share to Phenotype

Share to Tissue Array Analysis

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 29115585
DOI: 10.3892/ijo.2017.4186

Genes

IDH1
GSC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDH1 mutation diminishes aggressive phenotype in glioma stem cells.PMID 29115585Read ↗

R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/β-catenin signaling.Semantic proximity Read ↗

Exploring the regulatory role of isocitrate dehydrogenase mutant protein on glioma stem cell proliferation.Semantic proximity Read ↗

Expression of CD133 Cancer Stem Cell Marker in IDH-Mutant and IDH-wildtype (Isocitrate Dehydrogenase) Astrocytoma.Semantic proximity Read ↗

MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations.Semantic proximity Read ↗

IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells.Semantic proximity Read ↗

Unraveling the tumor-promoting role of wildtype Isocitrate dehydrogenase 1 (IDH1) in human gliomasSemantic proximity Read ↗

Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: possible impact on glioma cell metastasis and chemo-resistance.Semantic proximity Read ↗

IDH1 overexpression induced chemotherapy resistance and IDH1 mutation enhanced chemotherapy sensitivity in Glioma cells in vitro and in vivo.Semantic proximity Read ↗

Generation of induced neural stem cells with inducible IDH1R132H for analysis of glioma development and drug testing.Semantic proximity Read ↗

IDH1R132H mutation increases radiotherapy efficacy and a 4-gene radiotherapy-related signature of WHO grade 4 gliomas.Semantic proximity Read ↗

Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma.Semantic proximity Read ↗

Mutant IDH1 Promotes Glioma Formation In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.