Article

IDH1 <sup>R132H</sup> acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

2018-08-10

Abstract excerpt

<h4>One sentence summary</h4> Mutant IDH1 acts as a tumor suppressor when co-expressed together with TP53 and ATRX inactivating mutations in glioma, inducing genomic stability, DNA repair and resistance to genotoxic therapies. Glioma patients whose tumors carry a mutation in the Isocitrate Dehydrogenase 1 (IDH1 R132H ) gene are younger at the time of diagnosis and survive longer. The molecular glioma subtype whi...

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Literature Corpus work: 07f8fc0e-3f3d-5419-b1d3-633256eadebf
DOI: 10.1101/389817

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