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Article

Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a.

Scientific reports - 7 Apr 2023

Feng Zhebin, Kong Dongsheng, Jin Wei, He Kunyu, Zhao Junyan, Liu Bin, Xu Hanyun, Yu Xin'guang, Feng Shiyu

Abstract excerpt

The aim is to use Crispr-Cas12a for the rapid detection of the single nucleotide polymorphism (SNP) of isocitrate dehydrogenase 1 (IDH1)-R132H locus and explore the effectiveness and consistency of this method with direct sequencing method for detecting IDH1-R132H of glioma tissue samples. 58 previous frozen tissue and 46 recent fresh tissue samples of adult diffuse glioma were selected to detect IDH1-R132H using...

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Identifiers

PMID: 37029174
DOI: 10.1038/s41598-023-32957-y
PMCID: PMC10081818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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