Article
Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis.
Acta neuropathologica - 1 Feb 2018
Tiburcio Patricia D B, Xiao Bing, Berg Shauna, Asper Sydney, Lyne Sean, Zhang Yan, Zhu Xingen, Yan Hai, Huang L Eric
Abstract excerpt
Mutations of isocitrate dehydrogenase 1 (IDH1) gene are most common in glioma, arguably preceding all known genetic alterations during tumor development. IDH1 mutations nearly invariably target the enzymatic active site Arg132, giving rise to the predominant IDH1R132H. Cells harboring IDH1 R132H -heterozygous mutation produce 2-hydroxyglutarate (2-HG), which results in histone and DNA hypermethylation. Although...
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