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Article

Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model.

PloS one - 1 Jan 2018

Bala Usman, Leong Melody Pui-Yee, Lim Chai Ling, Shahar Hayati Kadir, Othman Fauziah, Lai Mei-I, Law Zhe-Kang, Ramli Khairunnisa, Htwe Ohnmar, Ling King-Hwa, Cheah Pike-See

Abstract excerpt

BACKGROUND: Down syndrome (DS) is a genetic disorder caused by presence of extra copy of human chromosome 21. It is characterised by several clinical phenotypes. Motor dysfunction due to hypotonia is commonly seen in individuals with DS and its etiology is yet unknown. Ts1Cje, which has a partial trisomy (Mmu16) homologous to Hsa21, is well reported to exhibit various typical neuropathological features seen in...

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PMID: 29795634
DOI: 10.1371/journal.pone.0197711
PMCID: PMC5967806

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