Article
Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.
Disease models & mechanisms - 12 Jun 2018
Aziz Nadine M, Guedj Faycal, Pennings Jeroen L A, Olmos-Serrano Jose Luis, Siegel Ashley, Haydar Tarik F, Bianchi Diana W
Abstract excerpt
Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in achieving developmental milestones. To determine whether different mouse models of DS recapitulate the human...
Topics
- Animals
- Animals, Newborn
- Behavior, Animal
- Brain
- Disease Models, Animal
- Down Syndrome
- Female
- Gene Expression Regulation
- Genome
- Hippocampus
- Longevity