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Article

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.

Disease models & mechanisms - 12 Jun 2018

Aziz Nadine M, Guedj Faycal, Pennings Jeroen L A, Olmos-Serrano Jose Luis, Siegel Ashley, Haydar Tarik F, Bianchi Diana W

Abstract excerpt

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in achieving developmental milestones. To determine whether different mouse models of DS recapitulate the human...

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Identifiers

PMID: 29716957
DOI: 10.1242/dmm.031013
PMCID: PMC6031353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.PMID 29716957Read ↗

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The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome.Semantic proximity Read ↗

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Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome.Semantic proximity Read ↗

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Duplication-based genetic dissection of the Down syndrome critical region reveals its complex functional organization.Semantic proximity Read ↗

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down SyndromeSemantic proximity Read ↗

Analysis of Adult Cerebral Cortex and Hippocampus Transcriptomes Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of D own SyndromeSemantic proximity Read ↗

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