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The impact of <i>Mmu</i> 17 non- <i>Hsa</i> 21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisited

2022-09-26

Abstract excerpt

Despite many successful preclinical treatment studies to improve neurocognition in the Ts65Dn mouse model of Down syndrome (DS), translation to humans has failed. This raises critical questions about the appropriateness of the Ts65Dn mouse as the “gold standard” for DS research given that it carries, in addition to Mmu16 orthologous genes, triplication of 50 Mmu 17 non-orthologous genes that might contribute to...

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Literature Corpus work
8c3b27a0-5543-50f9-9fc0-0a41e9c48e0f
DOI
10.1101/2022.09.23.509067
Open publication

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The impact of <i>Mmu</i> 17 non- <i>Hsa</i> 21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisitedDOI 10.1101/2022.09.23.509067
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