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Article

Using mouse models to explore genotype-phenotype relationship in Down syndrome.

Mental retardation and developmental disabilities research reviews - 1 Jan 2007

Salehi Ahmad, Faizi Mehrdad, Belichenko Pavel V, Mobley William C

Abstract excerpt

Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs. Sequencing of human chromosome 21 (HSA21) and subsequently of its orthologues on mouse chromosome 16 have created an unprecedented opportunity to explore the complex relationship between various DS phenotypes and the extra copy of approximately 300 genes on HSA21. Advances in genetics together with...

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PMID: 17910089
DOI: 10.1002/mrdd.20164

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NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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