Article

Neuronal overexpression of <i>DYRK1A/minibrain</i> alters motor decline, neurodegeneration and synaptic plasticity in <i>Drosophila</i>

2018-07-17

Abstract excerpt

Down syndrome (DS) is characterised by abnormal cognitive and motor development, and later in life by progressive Alzheimer’s disease (AD)-like dementia, neuropathology, declining motor function and shorter life expectancy. It is caused by trisomy of chromosome 21 (Hsa21), but how individual Hsa21 genes contribute to various aspects of the disorder is incompletely understood. Previous work has demonstrated a role...

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Literature Corpus work: 920e0412-64a2-5ba3-a560-399d247b0323
DOI: 10.1101/370924

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